CCL3L1 copy number and susceptibility to malaria
نویسندگان
چکیده
منابع مشابه
CCL3L1 copy number and susceptibility to malaria
Copy number variation can contribute to the variation observed in susceptibility to complex diseases. Here we present the first study to investigate copy number variation of the chemokine gene CCL3L1 with susceptibility to malaria. We present a family-based genetic analysis of a Tanzanian population (n=922), using parasite load, mean number of clinical infections of malaria and haemoglobin leve...
متن کاملCCL3L1 Copy Number Variation and Susceptibility to HIV-1 Infection: A Meta-Analysis
BACKGROUND Although several studies have investigated whether CCL3L1 copy number variation (CNV) influences the risk of HIV-1 infection, there are still no clear conclusions. Therefore, we performed a meta-analysis using two models to generate a more robust estimate of the association between CCL3L1 CNV and susceptibility to HIV-1 infection. METHODS We divided the cases and controls into two ...
متن کاملSDF-1 gene polymorphism and CCL3L1 gene copy number and susceptibility to HIV-1 / AIDS among Indians
Background Stromal derived factor (SDF-1) is a natural ligand for CXCR4 and chemokine (C-C) motif ligand 3-like 1 (CCL3L1) is for CCR5 HIV coreceptors. The individual role of the SNP in 3′ untranslated region of SDF-1 (SDF1-3′A) and low copy number of the CCL3L1 gene in determining susceptibility to HIV infection is well documented. The aim of the present study was to analyze the synergistic ef...
متن کاملCCL3L1 copy number, HIV load, and immune reconstitution in sub-Saharan Africans
BACKGROUND The role of copy number variation of the CCL3L1 gene, encoding MIP1α, in contributing to the host variation in susceptibility and response to HIV infection is controversial. Here we analyse a sub-Saharan African cohort from Tanzania and Ethiopia, two countries with a high prevalence of HIV-1 and a high co-morbidity of HIV with tuberculosis. METHODS We use a form of quantitative PCR...
متن کاملCopy number variation and susceptibility to complex traits
Copy number variations (CNV) within the genome are extremely abundant. In this closeup, Canales and Walz discuss how CNV are associated with normal variation, genomic disorders, genome evolution, adaptive traits and how the use of a novel screen described by Ermakova et al in this issue that is designed to identify human diseaserelevant phenotypes associated with CNV in the mouse can help eluci...
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ژورنال
عنوان ژورنال: Infection, Genetics and Evolution
سال: 2012
ISSN: 1567-1348
DOI: 10.1016/j.meegid.2012.03.021